Contact info:

krischan@egr.msu.edu
Phone: 517.432.4530
Fax: 517.555.5555

Cellular & Biomolecular Laboratory
Center for Systems Biology

PUBLICATIONS

Peer-reviewed Articles:

  1. Chan, C.; Arai, N.; Lior, N.; Churchill, S. W. "Thermally Stabilized Combustion as a Means of Studying the Devolatilization of Coal", Industrial Engineering and Chemical Research (1992) 31: 681-687. [DOI: 10.1021/ie00003a005]
  2. Churchill, S. W.; Chan, C. "Improved Correlating Equations for the Friction Factor for Fully Turbulent Flow in Round Tubes and between Identical Parallel Plates, both Smooth and Naturally Rough", Industrial and Chemical Engineering Research (1994) 33: 2016-2019. [DOI: 10.1021/ie00032a018]
  3. Churchill, S. W.; Chan, C. "Theoretically Based Correlating Equations for the Local Characteristics of Fully Turbulent Flow in Round Tubes and between Parallel Plates", Industrial and Chemical Engineering Research (1995) 34: 1332-1341. [DOI: 10.1021/ie00043a039]
  4. Churchill, S. W. and Chan, C. "Turbulent Flow in Channels in Terms of Local Turbulent Shear Stress and Normal Stresses", AIChE Journal (1995) 41: 2513-2521. [DOI: 10.1002/aic.690411202]
  5. Brown, M.; Chan, C.; Targett, M.; Holtzmuller, M.; Churchill, S. W. "Combustion of Ethane with Small Concentrations of Methyl Chloride in a Refractory Tube Burner", Combustion Science and Technology (1996) 115: 207-227. [DOI: 10.1080/00102209608935530]
  6. Heng, L.; Chan, C.; Churchill, S. W., "Essentially Exact Characteristics of Turbulent Convection in a Round Tube", Chemical Engineering Journal (1998) 71: 163-173. [DOI:10.1016/S1385-8947(98)00135-1]
  7. Washizu, J.; Chan, C.; Berthiaume, F.; Tompkins, R. G.; Toner, M.; Yarmush, M. L., "Amino Acid Supplementation Improves Cell-Specific Functions of the Rat Hepatocytes Exposed to Human Plasma", Tissue Engineering (2000) 6: 497-504. [DOI: 10.1089/107632700750022143 / PubMedID: 11074936]
  8. Washizu, J.; Berthiaume, F., Chan, C.; Tompkins, R. G.; Toner, M.; Yarmush, M. L. "Optimization of Rat Hepatocyte Culture in Citrated Human Plasma", Journal of Surgical Research (2000) 93: 237-246. [DOI: 10.1006/jsre.2000.5986 / PubMedID: 11027466]
  9. Chan, C.; Berthiaume, F.; Washuzu, J.; Toner, M.; Yarmush, M. L. "Metabolic Pre-Conditioning of Cultured Cells in Physiological Levels of Insulin: Generating Resistance to the Lipid Accumulating Effects of Plasma in Hepatocytes", Biotechnology and Bioengineering (2002) 78: 753-760. [DOI: 10.1002/bit.10275 / PubMedID: 12001167]
  10. Chan, C.; F.; Berthiaume, F.; Lee, K.; Yarmush, M. L. "Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma", Biotechnology and Bioengineering (2003) 81: 33-49. [DOI: 10.1002/bit.10453/ PubMedID: 12432579]
  11. Chan, C.; Hwang, D. H.; Stephanopoulos, G. N.; Yarmush, M. L.; Stephanopoulos, G. "Application of Multivariate Analysis to Optimize Function of Cultured Hepatocytes", Biotechnology Progress (2003) 19: 580-598. [DOI: 10.1021/bp025660h / PubMedID: 12675604]
  12. Chan, C.; Berthiaume, F.; Lee, K.; Yarmush, M. L. "Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma", Metabolic Engineering (2003) 5: 1-15. [DOI: 10.1016/S1096-7176(02)00011-3 / PubMedID: 12749840]
  13. Hwang, D. H.; Stephanopoulos, G.; Chan, C. "Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function", Bioinformatics (2004) 20: 487-499.[DOI: 10.1093/bioinformatics/btg433 / PubMedID: 14990444]
  14. Li, Z., and Chan, C. "Inferring pathways and networks with a Bayesian framework", FASEB J, (2004) 18(6): 746-748 (published on-line Feb 6, 2004). [DOI: 10.1096/fj.03-0475fje / PubMedID: 14766801]
  15. Kidambi, S.; Chan, C.; Lee, I. "Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Templates", JACS (2004) 126: 4697-4703. [DOI: 10.1021/ja039359o / PubMedID: 15070388]
  16. Li, Z., and Chan, C. "Integrating gene expression and metabolic profiles", Journal Biological Chemistry, (2004) 279: 27124-27137. [DOI: 10.1074/jbc.M403494200 / PubMedID: 15107427]
  17. Li, Z.; Yarmush, M. L.; Chan, C. "Insulin concentration during pre-conditioning mediates the regulation of urea synthesis in primary rat hepatocytes during exposure to amino acid supplemented plasma", Tissue Engineering, (2004) 10(11): 1737-1746. [DOI: 10.1089/ten.2004.10.1737]
  18. Chan, C.; Berthiaume, F.; Dwarakanath, B.; Tilles, A. W.; Toner, M.; Yarmush, M. L. "Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies", Liver Transplantation (2004) 10(11): 1331-1342. [DOI: 10.1002/lt.20229 / PubMedID: 15497161]
  19. Kidambi, S.; Lee, I.; Chan, C., "Controlling Primary Hepatocyte Adhesion and Spreading on Protein Free Polyelectrolyte Multilayer Films", JACS Communications, (2004) 126(50): 16286-16287. [DOI: 10.1021/ja046188u / PubMedID: 15600306]
  20. Patil, S. and Chan, C. "Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons", Neuroscience Lett., (2005) 384(3): 288-293. [DOI: 10.1016/j.neulet.2005.05.003 / PubMedID: 15939536]
  21. Li, Z., Shaw, S. M.; Yedwabnick, M. J.; Chan, C. "Using a state-space model with hidden variables to infer transcription factor activities", Bioinformatics, (2006) 22(6): 747-754. [DOI: 10.1093/bioinformatics/btk034 / PubMedID: 16403793]
  22. Patil, S.; Sheng, L.; Masserang, A.; Chan, C. "Palmitic acid-induced BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons", Neuroscience Lett., (2006) 406: 55-59. [DOI: 10.1016/j.neulet.2006.07.015 / PubMedID: 16904262]
  23. Srivastava, S.; Chan, C. "Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to MPT", Free Radical Research (2007) 41(1): 38-49. [DOI: 10.1080/10715760600943900 / PubMedID: 17164177]
  24. Kidambi, S.; Sheng, L.; Toner, M.; Yarmush, M.; Lee, I.; Chan, C. "Patterned Co-culture of Primary Hepatocytes and Fibroblasts using Polyelectrolyte Multilayer Templates", Macromolecular Bioscience (2007) 7(3): 344-353. [DOI: 10.1002/mabi.200600205 / PubMedID: 17370273]
  25. Kidambi, S.; Udpa, N., Schroeder, SA, Findlan, R, Lee, I, and Chan, C., "Cell Adhesion on Polyelectrolyte Multilayer Coated Poly(dimethylsiloxane) Surfaces with Varying Topographies", Tissue Engineering, (2007) 13(8): 2105-2117. [DOI: 10.1089/ten.2006.0151 / PubMedID: 17518734]
  26. Li, Z.; Srivastava, S.; Yang, S.; Mittal, S.; Norton, P.; Resau, J.; Chan, C. "A Hierarchical Approach to Identify Pathways that Confer Cytotoxicity in HepG2 Cells from Metabolic and Gene Expression Profiles", BMC Systems Biology (2007) 1(21): 1-15. [DOI: 10.1186/1752-0509-1-21 / PubMedID: 17498300 / [PMCID: PMC1885270]
  27. Li, Z.; Srivastava, S.; Mittal, S., Yang, X.; Sheng, L.; Chan, C. "A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways", BMC Bioinformatics (2007) 8(101): 1-17. [DOI: 10.1186/1471-2105-8-202 / PubMedID: 17570844 / PMCID: PMC1906836]
  28. Patil, S.; Melrose, J.; Chan, C. "Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons", European Journal of Neuroscience, (2007) 26(8): 2131-2141. [PubMedID: 17908174]
  29. Srivastava, S., Li, Z.; Yang, X.; Yedwabnick, M.; Shaw, S.; Chan, C. "Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity in hepatoma cells", BMC Genomics (2007) 8: 364. [DOI: 10.1186/1471-2164-8-364 / PubMedID: 17925029 / PMCID: PMC2110894]
  30. Srivastava, S. and Chan, C. "Application of Metabolic Flux Analysis to Identify the Mechanisms of Free Fatty Acid Toxicity to Human Hepatoma Cell Line, HepG2", Biotechnology and Bioengineering (2008) 99: 399-410. [DOI: 10.1002/bit.21568 / PubMedID: 17615559]
  31. Kidambi, S.; Lee, I.; Chan, C. "Tunable resistive m-dPEG acid patterns on polyelectrolyte multilayers at physiological conditions: template for directed deposition of biomacromolecules", Langmiur (2008) 24(1): 224 -230. [ DOI: 10.1021/la702925r / PubMedID: 18052083]
  32. Kidambi, S.; Lee, I.; Chan, C. "Primary Neuron/Astrocyte Co-Culture on Polyelectrolyte Multilayer Films: A Template for Studying Astrocyte-Mediated Oxidative Stress in Neurons", Advanced Functional Materials (2008) 18: 294-301. [DOI: 10.1002/adfm.200601237]
  33. Li, Z.; Srivastava, S.; Findlan, R.; Chan, C. "Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity", Biotechnology Progress (2008) 24(1): 29-37. [DOI: 10.1021/bp070120b]
  34. Leekumjorn, S.; Wu, Y.; Sum, A.K.; Chan, C. "Experimental and Computational Studies Investigating Trehalose Protection of HepG2 Cells from Palmitate Induced Cytotoxicity", Biophysical Journal (2008) 94: 1-15. [DOI: 10.1529/biophysj.107.120717]
  35. Patil, S.; Balu, D.; Melrose, J.; Chan, C. "Brain region specificity of palmitic acid-induced Alzheimer-like changes in primary neurons", BMC Research Notes (2008) 1: 20. [DOI:10.1186/1756-0500-1-20 / PubMedID: 18710535]
  36. Jin, R.; Si, L.; Chan, C. "A Bayesian Framework for Knowledge Driven Regression Model In Micro-array Data Analysis", International Journal of Data Mining and Bioinformatics (IJDMB) (2008) 2(3): 250-267. [PubMedID: 19024497]
  37. Srivastava, S.; Zhang, L.; Jin, R.; Chan, C. "A Novel Method Incorporating Gene Ontology Information for Unsupervised Clustering and Feature Selection", PLoS ONE (2008) 3(12): e3860-3867. [DOI: 10.1371/journal.pone.0003860 / PubMedID: 19052637 / PMCID: PMC2585795]
  38. Yang, X.; Chan, C.; "Repression of PKR Mediates Palmitate-Induced Apoptosis in HepG2 Cells through Bcl-2”, Cell Research (2009) 19(4): 469-486. [DOI: 10.1038/cr.2009.25 / PubMedID: 19259124 / PMCID: PMC2664847]
  39. Dalkic, E.; Nash, D. E. W.; Fassia, M. K.; Chan, C.; "Integrative Analysis of Cancer Pathway Progression”, Proteomics–Clinical Applications (2009) 3: 473-485. [DOI: 10.1002/prca.200800074 / PubMedID: 21136972 / PMCID: PMC3033602]
  40. Mehrotra, S.; Lee, I.; Chan, C.; "Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios”, Acta Biomaterialia (2009) 5:1474-1488. [DOI: 10.1016/j.actbio.2009.01.004 / PubMedID: 19217360 / PMCID: PMC2677632]
  41. Leekumjorn, S.; Cho, H. J.; Wu, Y.; Wright, N. T.; Sum, A.K.; Chan, C.; "The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes”, Biochimica et Biophysica Acta-Biomembranes (2009) 1788(7): 1508-1516. [ DOI: 10.1016/j.bbamem.2009.04.002 / PubMedID: 19371719 / PMCID: PMC2698950]
  42. Yang, X.; Zhou, Y.; Jin, R.; Chan, C.; "Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization”, Bioinformatics (2009) 25(17):2236-2243. [DOI: 10.1093/bioinformatics/btp376 / PubMedID: 19542155 / PMCID: PMC2800351]
  43. Mehrotra, S.; Lynam, D.; Maloney, R.; Pawelec, K. M.; Tuszynski, M.; Lee, I.; Chan, C.; Sakamoto, J. "Time controlled protein release from layer-by-layer assembled multilayers functionalized agarose hydrogels", Advanced Functional Materials (2009) 19: 1-12. [DOI: 10.1002/adfm.200901172 / PubMedID: 20200599 / PMCID: PMC2830720]
  44. Wu, M.; Yang, X.; Chan, C. "A dynamic analysis of insulin signaling and its feedback mechanisms: A discrete modeling approach", PLoS One (2009) 4(120): e8040(1-12). [DOI: 10.1371/journal.pone.0008040 / PubMedID: 19956598 / PMCID: PMC2779448]
  45. Dalkic, E.; Wang, X.; Wright, N. T.; Chan, C. "Cancer-Drug Associations: A Complex System", PLoS One (2010) 5(4): e10031. [DOI: 10.1371/journal.pone.0010031 / PubMedID: 20368808 / PMCID: PMC2848862]
  46. Zhang, L.; Seitz, L. C.; Abramczyk, A. M.; Chan, C. "Synergistic effect of cAMP and palmitate in promoting altered mitochondria function and cell death in HepG2 cells", Experimental Cell Research (2010) 316: 716-727. [DOI: 10.1016/j.yexcr.2009.12.008 / PubMedID: 20026039 / PMCID: PMC2826503]
  47. Zhang, L.; Chan, C. "Isolation and Enrichment of Rat Mesenchymal Stem Cells (MSCs) and Separation of Single-colony Derived MSCs", Journal of Visualized Experiments (2010) Mar 22;(37) pii:1852. [DOI: 10.3791/1852 / PubMedID: 20308982]
  48. Portis, A. M.; Carballo, G.; Baker, G. L.; Chan, C.; Walton, S. P. "Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles", Microscopy Research and Technique (2010) 73: 878-885. [DOI: 10.1002/jemt.20861 / PubMedID: 20803695 / PMCID: PMC2931363 (Available on 2011/9/1)]
  49. Gredell, J. A.; Dittmer, M. J.; Wu, M.; Chan, C.; Walton, S. P. "Recognition of siRNA Asymmetry by TAR RNA Binding Protein", Biochemistry (2010) 49(14): 3148-3155. [DOI: 10.1021/bi902189s / PubMedID: 20184375 / PMCID: 2851484]
  50. Patil, S. P.; Maki, S.; Khedkar, S. A.; Rigby, A. C.; Chan, C. "Withanolide-A and asiatic acid modulate multiple targets associated with AβPP processing and Aβ clearance", Journal of Natural Products (2010) 73: 1196-1202. [NIHMS214809 / DOI: 10.1021/np900633j / PubMedID: 20553006 / PMCID: PMC2917495]
  51. Mehrotra, S.; Hunley, C.; Pawelec, K. M.; Zhang, L.; Baek, S.; Chan, C. "Cell adhesive response and substrate displacement modeling of thin polyelectrolyte multilayers in linear growth regime", Langmuir (2010) 26(15): 12794-12802. [NIHMS220280 / DOI:10.1021/la101689z]
  52. Cho, H. J.; Mukherjee, S.; Palasuberniam, P.; Pillow, L.; Bilgin, B.; Nezich, C. L.; Walton, S. P.; Feig, M.; Chan, C. "Molecular Mechanism by Which Palmitate Inhibits PKR Autophosphorylation", Biochemistry (2011) 50(6): 1110-1119. [DOI:10.1021/bi101923r / PubMedID: 21192654 / PMCID: PMC3035770]
  53. Yang, X.; Nath, A.; Opperman, M. J.; Chan, C. "The double-stranded RNA–dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells", Molecular Biology of the Cell (2010) 21: 3449-3458. [DOI:10.1091/mbc.E10-06-0481 / PubMedID: 20685959 / PMCID: PMC2947480]
  54. Zhang, L.; Seitz, L. C.; Abramczyk, A. M.; Liu, L.; Chan, C. "cAMP initiates early-phase neuron-like morphological changes and late-phase neural differentiation and function in mesenchymal stem cells", Cellular and Molecular Life Sciences (2010) 68(5): 863-876. [DOI:10.1007/s00018-010-0497-1 / PubMedID: 20725762 / PMCID: PMC3030935 (Available on 2012/3/1)]
  55. Mehrotra, S.; Liu, C.; Lee, I.; Chan, C. "Polyelectrolyte multilayer stamping in aqueous phase and non-contact mode", Industrial & Engineering Chemistry Research (2011) 50(15): 8851–8858. [DOI:10.1021/ie102011m]
  56. Mehrotra, S.; Lynam, D.; Liu, C.; Lee, I.; Tuszynski, M.; Sakamoto, J.; Chan, C. "Time Controlled Release of Arabino-furanosylcytosine (Ara-C) from Agarose Hydrogels using Layer-By-Layer Assembly: An In-vitro Study", Journal of Biomaterials Science, Polymer Edition (2011) 23: 439–463. [DOI:10.1163/092050610X552221]
  57. Wu, M.; and Chan, C. "Learning transcriptional regulation on a genome scale: a theoretical analysis based on gene expression data", Briefings in Bioinformatics (2011) May 26, p. 1–12 [DOI:10.1093/bib/bbr029].
  58. Geekiyanage, H.; and Chan, C. "MicroRNA-137/181c regulate serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer’s disease", Journal of Neuroscience (2011) 31(41): 14820-14830. [DOI:10.1523/?JNEUROSCI.3883-11.2011]
  59. Wang, X.; Yang, X.; Nath, A.; Chan, C. "Desmoplakin: Synergy analysis reveals a new player in the pathogenesis and progression of fatty liver disease", Plos One (2011) 6(11): e28138. [DOI:10.1371/journal.pone.0028138]
  60. Wu, M.; Liu, L.; Chan, C. "Identification of novel targets for breast cancer by exploring gene switches on a genome scale", BMC Genomics (2011) 12:547. [DOI:10.1186/1471-2164-12-547]
  61. Geekiyanage, H.; Jicha, G. A.; Nelson, P. T.; and Chan, C. "Blood serum miRNA: Non-invasive biomarkers for Alzheimer’s disease", Experimental Neurology (2011) (in press).
  62. Li, L.; Martin, R.; and Chan, C. "Palmitate-activated astrocytes via SPT increases BACE1 in primary neurons by SMases", (2011) (in review).
  63. Zhang, L.; Thompson, R.; Liu, L.; Chan, C. "CREB modulates calcium signaling elicited by neuronal activators in mesenchymal stem cells", (2011) (in review).
  64. Baek, S.; Liu, C.; Lee, J. A.; Hunley, S. C.; Whitman, J.T.; Mehrotra, S.; Chan, C. "A computational method for predicting cellular orientation based on the concept of active mechanosensing", (2011) (in review).
  65. Cho, H. J.; Wu, M.; Zhang, L.; Thompson, R.; Nath, A.; and Chan, C. "Palmitate-induced dysregulation of ER-related stress responses in HepG2 cells mediated by ATF4 and CREB", (2011) (to be submitted).

Invited / Peer Reviewed Book Chapters and Reviews:

  1. Berthiaume, F.; Chan, C.; Yarmush, M. L. "Liver, Bio-artificial", in Encyclopedia of Biomaterials and Biomedical Engineering, eds. Gary Wnek and Gary Bowlin, Marcel Dekker Inc., New York, NY, 2004, Vol. 1: 899-909. [pdf]
  2. Li, Z.; Chan, C. "Extracting novel information from gene expression data", (2004) Trends in Biotechnology 22: 381-383. [PubMedID: 15283978]
  3. Patil, S.; Li, Z.; Chan, C. "Cellular to Tissue Informatics: Approaches to Optimizing Cellular Function of Engineered Tissue", in Advances in Biochemical Engineering/Biotechnology, eds. K. Lee and D. Kaplan, Springer, 2006, Vol. 102: 139-159. [PubMedID: 17089789]
  4. Walton, S. P.; Li, Z, and Chan, C, "Biological network analyses: computational genomics and systems approaches", (2006) Molecular Simulation 32 (Issue 3-4, 15 March-April): 203-209.
  5. Berthiaume, F.; Tilles, A. W.; Toner, M.; Yarmush, M. L.; Chan, C. "Hepatic Tissue Engineering for Adjunct and Temporary Liver Support", in Tissue Engineering and Artificial Organs, ed. Joseph D. Bronzino, Taylor and Francis, Boca Raton, FL, 2006, Chapter 59: 1-19. [pdf]
  6. Chan, C.; Li, Z.; Srivastava, S. "Integration of Micro-Array and Metabolic Data", in Mathematical Modeling in Experimental Nutriton, 2007, Chapter 5: 82-96. [pdf]
  7. Srivastava, S.; Li, Z.;and Chan, C.; (2009) "Identification of gene-networks associated with cell-death in lipotoxicity", in Methods in Molecular Biology: Caspase Regulation, ed. Jeffrey Varner, Humana Press Inc.; Totowa, NJ (2010) (in press).
  8. Wang, X.; Wu, M.; Li, Z.; Chan, C. "Short time-series microarray analysis: methods and challenges", (2008) BMC Systems Biology, 2: 58. [PubMedID: 18605994]
  9. Wang, X.; Wu, M.; Dalkic, E.; Chan, C. "Gene-module level analysis: Identification to Networks and Dynamics", (2008) Current Opinion in Biotechnology 19: 482-491. [DOI: 10.1016/j.copbio.2008.07.011 / PubMedID: 18725293 / PMCID: PMC2615490]
  10. Chan, C.; Wang, X.; Book review of Systems Biological Approaches in Infectious Diseases, edited by Helen I. Boshoff and Clifton E. Barry, III, (2009) ChemMedChem, 4: 1-3.
  11. Li, Z.; Chan, C. "Systems biology for identifying liver toxicity pathways", (2009) BMC Proceedings, 3(Suppl 2):S2 (10 March 2009). [PubMedID: 19278558 / PMCID: PMC2654485]
  12. Yang, X.; Wang, X.; Wu, M.; Dalkic, E.; Chan, C. "Construction of the gene network by synergy analysis of the genes related to palmitate-induced cytotoxicity", Methods in Bioengineering in Systems Analysis of Biological Networks, eds. Arul Jayaraman & Juergen Hahn, Artech House Publishers (2009), Chapter 5, pp. 75-93.
  13. Walton, S. P.; Wu, M.; Gredell, J.; and Chan, C. "Designing highly active siRNAs for therapeutic applications", FEBS Journal (2010) 277: 4806-4813. [DOI: 10.1111/j.1742-4658.2010.07903.x / PubMedID: 21078115 / PMCID: PMC3052974 (Available on 2011/12/1)]
  14. Malefyt, A.P.; Angart, P.A.; Chan, C.; and Walton, S.P. "siRNA Therapeutic Design: Tools and Challenges", Regulatory RNAs, Springer (2011), in press.

Manuscripts to be submitted:

  1. Dalkic, E. "Targets from Comparative Network Analysis of Colorectal Cancer with Other Cancers", (2010) (to be submitted in December).

Others:

  1. Chan, C. and Tannenbaum, P. "1997 Inter-Society Color Council Annual Meeting and the Color & Appearance Division of the Society of Plastics Engineers", (1998) Color Research and Application 23.
  2. Huebner, M.; Kroos, L.; Chan, C.; Sun, F.; and Cheng, T. "Biological Networks: Design and Dynamics at Different Levels", Department of Statistics and Probability, Technical Report MSU, RM639 (2004)
  3. Jin, R.; Si, L.; Chan, C. "Improve the Linear Regression Model in Bioinformatics Using Text Mining", Technical Report (MSU-CSE-06-9) of Computer Science and Engineering Dept. of MichiganStateUniversity. (2006) [pdf]


Conference Papers

Peer-reviewed conference papers:

  1. Wu, M.; Yang, X.; Chan, C.; "A dynamic analysis of insulin signaling and its feedback mechanisms: A discrete modeling approach", the RECOMB Regulatory Genomics and Systems Biology (2009).
  2. Zhou, Y.; Li, Z.; Yang, X.; Zhang, L.; Srivastava, S.; Jin, R.; Chan, C. "Using Knowledge Driven Matrix Factorization to Reconstruct Modular Gene Regulatory Network", the Twenty-Third AAAI Conference on Artificial Intelligence (AAAI-08) (2008).
  3. Jin, R.; Si, L.; Srivastava, S.; Li, Z. and Chan, C. "A Knowledge Driven Regression Model for Gene Expression and Microarray Analysis", In Proceedings of 28th Annual International Conference IEEE Engineering in Medicine and Biology Society (2006).

Non-refereed papers and Extended Abstracts:

  1. Wu, M.; Yang, X.; Chan, C. "A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach", Joint RECOMB Satellite Conference on Regulatory Genomics, Systems Biology, Dream4 (2009).
  2. Wang, X.; Yang, X.; Nath, A.; Zhang, L.; Chan, C. "Reconstructing Gene Cooperation Network of Lipotoxicity by Synergy Analysis", 2009 Joint RECOMB Satellite Conference on Regulatory Genomics, Systems Biology, Dream4 (2009).
  3. Dalkic, E.; Chan, C. "Distinct topological changes of the different cancer types", 2009 Joint RECOMB Satellite Conference on Regulatory Genomics, Systems Biology, Dream4 (2009).
  4. Kidambi, S.; Lee, I.; Chan, C. "Aptamer Incorporated Polyelectroyte Multilayer Films Targeting Influenza Virus Hemagglutinin", ACS Polymer Preprints (2007).
  5. Kidambi, S.; Lee, I.; Chan, C. "Salt Tunable m-dPEG Acid Patterns on Polyelectrolyte Multilayers - Templates for Directed Deposition of Macromolecules", ACS Polymer Preprints (2006).
  6. Kidambi, S.; Lee, I.; Chan, C., "Polyelectrolyte Multilayer as Bioactive Surface for Cell Adhesion", ACS Polymer Preprints (2005).
  7. Li, Z.; Srivastava, S.; Chan, C., "Integrating Gene Expression and Metabolic Profiles to Infer Pathways and Networks that Confer Palmitate Induced Cytotoxicity in HEPG2 Cells", ASME Summer Bioengineering Conference Proceedings (2005).
  8. Kidambi, S.; Lee, I.; Chan, C. "Selective Primary Hepatocyte Adhesion on Polyelectrolyte Multilayer: Template for Patterned Cell Co-Culture," AIChE Nanotechnology Preprint (2004).
  9. Kidambi, S.; Lee, I.; Chan, C. "Engineering Polyelectrolyte Multilayer (PEM) Surfaces to Create Cell Resistant and Adhesive Surfaces," Polymer Preprints 45(1), 88-89 (2004).
  10. Chan, C. and Li, Z. "Inferring the Hepatic Network from Experimental Measurements using Bayesian Network Analysis", ASME Summer Bioengineering Conference Proceedings (2003).
  11. Chan, C.; Hwang, D. H.; Stephanopoulos, G.; Stephanopoulos, G.; N.; Yarmush, M. L. "Application of Multivariate Analysis for Optimizing & Predicting Hepatic Function", BMES (2002).
  12. Chan, C.; Hwang, D. H.; Stephanopoulos, G.; Stephanopoulos, G.; N.; Yarmush, M. L. "Application of Metabolic Engineering and Multivariate Analyses for Optimizing Hepatic Function", Metabolic Engineering IV: Applied Systems Biology (2002).
  13. Chan C.; Washizu, J.; Berthiaume F.; Toner, M.; Yarmush, M. L. "Application of Metabolic Engineering to Cellular Processes of the Liver: As Use in the Development of the Bioartificial Liver", ASME Summer Bioengineering Conference Proceedings, 50: 357-358 (2001).
  14. Chan, C.; Berthiaume, F.; Washuzu, J.; Toner, M.; Yarmush, M. L. "The Effect of Conditioning on Lipid Metabolism of Hepatocytes in Plasma", Metabolic Engineering III (2000).