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Bladder Diagram
We are interested in understanding the effect that peripheral neuropathy, in type II diabetes, and spinal cord injury have on the function and microstructure of the urinary bladder wall. We focus primarily on the changes in the bladder extracellular matrix.
Two complementary biomechanical modelling approaches
We used two complementary biomechanical modelling approaches—a mechanistic mixture-based finite-element model, and a phenomenological continuum-based semi-analytic model—to illustrate these potentially good, bad and ugly roles of medial GAGs/PGs in large arteries.
Graphic of the radial stress (kPa) of the human thoracic aorta
Spontaneous dissection of the human thoracic aorta is responsible for significant morbidity and mortality, yet this devastating biomechanical failure process remains poorly understood. Aortic dissection occurs when a tear in the inner wall of the aorta causes blood to flow between the layers and forces them apart.
Photo of an example of a multilayered structure under finite bending
Natural (geological formations, biological materials) and man-made (sandwich panels, submarine coatings, microelectronic devices) structures are often made of layers of different materials glued together, the so-called ‘multilayers’. The possibility of achieving large deformations in these structures is limited by the occurrence of various forms of bifurcations. For instance, compressive strain is limited by buckling and subsequent folding, uniform tensile strain may terminate with shear band formation and growth, while bending may lead to the formation of bifurcation modes such as undulations and creases. Bifurcation is therefore an important factor in the design of multilayered materials.