We develop high performance therapeutics and diagnostics using novel protein engineering methods. Our lab combines directed evolution and high-throughput experiments with structural biology and bioinformatics to elucidate biological processes and their clinical relevance.
PhD, University of Minnesota, Chemical Engineering, 2017
BS, Michigan Technological University, Chemical Engineering, 2011
Woldring DR, Holec PV, Stern LA, Du Y & Hackel BJ. Sitewise Diversity to Optimize Evolutionary Fitness of a Three-helix Bundle Combinatorial Library. Biochemistry 2017
Kruziki MA, Case BA, Chan JY, Zudock EJ, Woldring DR, Yee D & Hackel BJ. A 64Cu-Labeled Gp2 Domain for PET Imaging of Epidermal Growth Factor Receptor. Molecular Pharma. 2016
Woldring DR, Holec PV & Hackel BJ. ScaffoldSeq: Software for Characterization of Directed Evolution Populations. Proteins: Structure, Function and Bioinformatics 2016
Woldring DR, Holec PV, Zhou H & Hackel BJ. High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains. PLoS One 2016