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Tim Whitehead

Tim Whitehead

Tim Whitehead

Adjunct Faculty of ChEMS

Biography

My group develops general methods to engineer and design biological macromolecules for new and/or enhanced functions. These molecules can be useful as biocatalysts to deconstruct renewable biomass to jet fuel, as diagnostics or therapeutics for recognizing and destroying pandemic viruses, and comprise new metabolic pathways for the environmentally friendly production of medicines. 

Awards
2017 Young Scientist Keynote, PEGS Global Summit
Fellow, Global Academy 2015
NSF Career Award 2013
Education
Ph.D., Chemical Engineering, University of California, Berkeley, 2008
B.E., Chemical Engineering, Vanderbilt University, 2001
Publications
Klesmith JR, Bacik JP, Wrenbeck EE, Michalczyk R, Whitehead TA (2017) “Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning”, PNAS in press
Wrenbeck EE, Klesmith JR, Adeniran A, Stapleton JA, Tyo KJ, Whitehead TA, (2016) “Plasmid-based single-pot saturation mutagenesis”, Nature Methods 13(11): 928-930 doi:10.1038/nmeth.4029
Kowalsky CA, Faber M, Nath A, Dann H, Kelly VW, Liu L, Shanker P, Wagner EK, Maynard J, Chan C, Whitehead TA (2015) “Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing”, Journal of Biological Chemistry 290 (44), 26457-26470 doi:10.1074/jbc.M115.676635
Stapleton JA, Whitehead TA, Nanda V (2015) “Computational redesign of the lipid-facing surface of the outer membrane protein OmpA”, PNAS 112(31):9632-9637
MSU Scholars ID
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