Biography
Our laboratory applies cellular, molecular engineering and systems biology approaches to investigate disease mechanisms. We are studying endoplasmic reticulum (ER) stress related diseases, in particular, we are interested in how fatty acids interact with ER transmembrane sensor proteins to drive the development of cancer metastasis and neurological diseases. Our laboratory also is developing therapeutics using engineering approaches (e.g. drug delivery systems and stem cell engineering techniques) to modulate the pathways altered in these diseases.
Awards
Recipient of the AIChE Area Forum 15D/E Engineering Fundamentals in Life Science Plenary Lecture Award, 2015
Beal Outstanding Faculty Award (formerly University Distinguished Faculty Award), 2014
Withrow Distinguish Scholar Award, 2014
Engineering’s College of Fellows, 2012
Elected to the American Institute for Medical and Biological, 2011
Withrow Excellence in Teaching Award, 2010
Whitaker Young Investigator Award, 2003-2006
National Academy of Engineering invitation to "Frontiers in Engineering", 2004
Research Group
Education
Ph.D, Chemical and Biochemical Engineering, University of Pennsylvania 1990
M.S., Chemical and Biochemical Engineering, University of Pennsylvania 1986
Publications
C. Chan, S.T. Foster, K.G. Chan, M.J. Cacace, S.L. Ladd, C.T. Sandum, P.T. Wright, and N.T. Wright, “Repositioned drugs for COVID-19 – impact on multiple organs”, SN Comprehensive Clinical Medicine (2021).
D. Vocelle, C. Chan, S. P. Walton, “Endocytosis controls sirna efficiency: implications for sirna therapeutic design and cell specific targeting” Nucleic Acid Therapeutics, 30:1, 22-32 (2020).
T.A. Whitehead, et al. “The importance and future of biochemical engineering”, Biotechnology and Bioengineering, 117:8, 2305-2318 (2020).
D. Vocelle, O. Chesniak, M.R. Smith, C. Chan, and S.P. Walton, “Kinetic analysis of the intracellular processing of sirnas by confocal microscopy”, Microscopy, 69:6, 401-407 (2020).
Primary Department
Other Departments
