I received my B.Sc. degree in Molecular Genetics from King’s College London (UK), my Ph.D. in Experimental Oncology from Karolinska Institute (Sweden) and postdoctoral training in Cancer Chemotherapy from Stanford University (USA). My current research interest is to understand the biology and the function of extracellular vesicles (EVs) both in physiological and pathophysiological condition, aiming to develop a novel tool for diagnostics and treatment. Engineered EVs are used for visualization, monitoring and targeted-delivery of oligonucleotide therapeutics, including non-coding RNAs (microRNAs), DNAs and CRSPR-CAS9 as well as low-molecular weight drugs to develop advanced treatment. The ultimate goal of my research is to translate basic scientific findings into clinical applications.
Biography
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Publications
Lohcharoenkal W, Harada M, Lovén J, Meisgen F, Landén NX, Zhang L, Lapins J, Mahapatra KD, Shi H, Nissinen L, Kähäri VM, Ståhle M, Sonkoly E, Grandér D, Arsenian-Henriksson M, Pivarcsi A., MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC. J Invest Dermatol (2016) 136(12):2485-2494.
Harada M., Benito, J., Yamamoto, S., Kaur, S., Arslan, D., Ramirez, S., Jacamo, R., Platanias, L., Matsushita, H., Fujimura, T., Kazuno, S., Kojima, K., Tabe, Y., Konopleva, M., The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget (2015) Nov 10;6(35):37930-47
Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grander D, Stahle M, Sonkoly E, Pivarcsi A., MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration and Invasion. J Biol Chem. (2012) Jul 10
Harada M, Pokrovskaja Tamm K, Soderhall S, Heyman M, Grander D, et al. (2012) Involvement of the miR17 pathway in glucocorticoid -induced cell death in pediatric acute lymphoblastic leukemia. Leuk Lymphoma.
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn M, Hedblad M-A, Hippe A, Grandér D, Homey B, Zaphiropoulos PG, Arsenian-Henriksson M, Ståhle M and Pivarcsi A. (2012) MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis 1, e3
Lerner M, Haneklaus M, Harada M, Grander D (2012) MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors. PLoS One 7: e36490
E Buentke, A Nordström, H Lin, A-C Björklund, E Laane, M Harada, L Lu, T Tegnebratt, S Stone-Elander, M Heyman, S Söderhäll, A Porwit, C-G Östenson, M Shoshan, K Pokrovskaja Tamm & D Grandér. Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells. Blood Cancer Journal 1, e31(2011)
Lerner M, Harada M, Loven J, Castro J, Davis Z, et al. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Exp Cell Res 315: 2941-2952 (2009)
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