Research update - Systematically monitoring wastewater

May 19, 2022

Irene Xagoraraki continues to hunt pathogens in wastewater

The country’s Centers for Disease Control (CDC) and Prevention are actively tracking pathogens, like the SARS-CoV-2 virus that causes COVID-19, in wastewater at thousands of testing sites across the country.

Professor Irene Xagoraraki leads the research team for one of Michigan’s largest and oldest wastewater monitoring projects. (Photo by Dale Young, courtesy of Detroit News.)   
Professor Irene Xagoraraki leads one of Michigan’s largest and oldest wastewater monitoring projects. (Photo by Dale Young, courtesy of Detroit News.)  

Among them is Detroit’s wastewater site, which is characterized as a sentinel site for the CDC, says Michigan State University environmental engineering professor Irene Xagoraraki, who leads one of the state's largest wastewater monitoring projects.

Xagoraraki said her team is perfectly positioned to monitor Detroit's wastewater for the virus that causes COVID-19 because she and her students were the only researcher group in Michigan who was systematically monitoring wastewater for pathogens prior to the pandemic and were able to predict a Hepatitis A outbreak in the region in 2017-18.

Liang Zhao and Yabing Li load wastewater samples into a machine at MSU seeking to detect SARS viruses. (Photo by Dale Young, courtesy of Detroit News.)   
Liang Zhao and Yabing Li load wastewater samples seeking to detect SARS viruses. (Photo by Dale Young, courtesy of Detroit News.)  

She said Southeast Michigan’s sewer collection network includes three interseptors that provide samples from the majority of the tri-county area. It allows her team to collect samples that cover three county health departments and the Detroit health department.

Her research team includes postdoctorate researchers Yabing Li and Yangyang Zou, Ph.D. students Brijen Miyani and Liang Zhao, master’s students Maddie Spooner and Zach Gentry, and Sydney Jacobi, a junior in biosystems engineering.

 Maddie Spooner and Brijen Miyani conduct RNA extraction. (Photo by Dale Young, courtesy of Detroit News.)   
Maddie Spooner and Brijen Miyani conduct RNA extraction. (Photo by Dale Young, courtesy of Detroit News.)

Xagoraraki’s research on Detroit wastewater began in 2017 with a National Science Foundation grant that focused on Hepatitis and other viral diseases. In 2020, she received $800,000 from the Michigan Department of Environment, Great Lakes and Energy, and $267,000 from the Great Lakes Water Authority.

"For 2021-2023, my research group is working with $3.7 million from the Michigan Department of Health and Human Services to survey wastewater in the Detroit Metropolitan area and create and validate and viral disease prediction model.

Liang Zhao seeks to find pathogen gene markers, which can then be reported to health departments. (Photo by Dale Young, courtesy of Detroit News.)
Liang Zhao looks for pathogen gene markers to report to health departments. (Photo by Dale Young, courtesy of Detroit News.)

"The hope is that COVID-19 will die out but the application of this methodology is critical in detecting other endemic or emerging viral infections in the population of the Detroit tri-county area,” she added.

Read more on Xagoraraki’s research at MSUToday.