Research in the Aguirre Lab focuses on investigating cell plasticity and tissue remodeling in health and disease. We use a combination of zebrafish genetics, human stem cells, biochemistry, functional genomics, metabolomics and tissue engineering approaches to dissect signaling pathways and understand how the cardiovascular system develops, ages and responds to injury or disease states. This information will allow us to better understand and treat congenital and pediatric disorders, and will be critical to develop new regenerative medicine therapies to promote tissue regeneration and slow down the aging process.
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