Severe plastic deformation techniques are well known to provide outstanding mechanical properties for the fabricated materials. However, both bulk and surface biocompatibilities are required in the case of the biomedical materials. Last decades, microstructural refinement through SPD was operated to biomedical metallic materials such as titanium alloys, stainless steel, cobalt-chromium alloys, and biodegradable metals. Moreover, the SPD-processed material reveals well-improved mechanical biocompatibility such as great hardness, high strength and adequate ductility. In surface biocompatibility, the electrochemical behavior (corrosion and tribocorrosion) and the cell-substrate response have been significance. In the common sense, the deformation reduced the corrosion resistance of the materials due to the complex and active dislocation-rich structure. However, the studies on the ultra-fine / nano structured titanium and cobalt alloys exhibited almost no different behavior after severe deformation due to the quick forming of the passive film. Recent immune-plotting and immuno-fluorescence studies revealed that the ultra-fine / nano structured surface leads to enhance protein adsorption and subsequently cell adhesion, proliferation, and differentiation. The repeating ultrafine and nano structures of the SPD- processed materials have triggered an high surface energy which effects on the cell media and cellular functions. Decisively, the benefits and challenges considering the SPD techniques to produce biocompatible materials are promising.
Hakan Yılmazer has been served as an assistant professor in Department of Metallurgical and Materials Engineering at Yıldız Technical University, Turkey since 2015, He earned Ph.D degree in Department of Materials Science at Tohoku University, Japan at 2012. He served as postdoctoral researcher in Institute for Materials Research of Tohoku University from 2012 to 2015. During Ph.D, He also served as an research assistant at Institute for Materials Research of Tohoku University under the program of Global Certificate of Center of Excellence supported by Japan Government since 2008. He served as an research fellow of The Scientific and Technological Research Council of Turkey at Department of Mechanical Engineering at Istanbul Technical University under a program from 2006 to 2008. He earned BSc and MSc degrees in Department of Metallurgical and Materials Engineering at İstanbul Technical University. His research interests include: areas of processing-microstructure-mechanical/functional property relationships focusing on Metallic Biomaterials, Severe Plastic Deformation, Ultrafine grained and Nanostructured materials, Non-ferrous metallic materials, Metal Matrix Composites, and Biodegradable Materials.