November 2018

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BME/IQ Speaker: Jason Bazil, PhD

BME/IQ Speaker: Jason Bazil, PhD

Event Date/Time: 
November 7, 2018 - 11:00am to 12:00pm
Event Location: 
IQ Atrium (775 Woodlot Dr)
Speaker: 
Jason Bazil
Elucidating the Mechanism of Calcium-Induced Inhibition of Mitochondrial Metabolism

Ischemic myocardium is characterized by a chronic elevation in cellular calcium concentration. In this setting, mitochondria accumulate calcium to levels that compromise their ability to synthesize ATP. Although total mitochondrial calcium can reach up to 1 M, the vast majority is presumed to be present as insoluble calcium phosphate granules. Our group recently reported calcium levels below thresholds that trigger mitochondrial permeability transition significantly lowers the rate of ADP-stimulated respiration. In this seminar, we will go over our recent findings that elucidate the mechanism of calcium-dependent inhibition of mitochondrial metabolism. We used both experimental and computational modeling approaches to test a variety of possible mechanisms capable of explaining the data. For the computational hypothesis testing, we developed a new mitochondrial bioenergetics model that includes the explicit representation of calcium phosphate granule formation in addition to calcium uptake and efflux pathways. Based on our functional data and model analyses, accumulated calcium phosphates inhibiting complex I best explained these data. In addition, our cryo-transmission electron microscopy images of calcium loaded mitochondria reveal the destabilization of cristae structure and resultant decrease in complex I activity is the mechanism that leads to the observed calcium-dependent decrease in ADP-stimulated respiration.

 

Join from PC, Mac, iOS or Android: https://msu.zoom.us/j/740946330

Or join by phone: +1 646 876 9923 / Meeting ID: 740 946 330

11/07/2018 - 11:00am to 12:00pm
 
 
 
 
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Oncogenomic Tenets of Precision Oncology Symposium

Oncogenomic Tenets of Precision Oncology Symposium

Event Date/Time: 
November 12, 2018 - 3:00pm to 5:00pm
Event Location: 
Facility for Rare Isotope Beams, 604 South Shaw Lane, East Lansing, MI 48824
Speaker: 
Oncogenomic Tenets of Precision Oncology Symposium

Join the Institute of Quantitative Health Science & Engineering (IQ) for the Oncogenomic Tenets of Precision Oncology Symposium, to be held Monday and Tuesday, November 12 and 13 at the FRIB Auditorium at Michigan State University.


This symposium is aimed at an audience from undergraduate students to professionals in the fields of genomics and cancer. It will be an excellent opportunity for academics and potential industrial partners to have open discussions about opportunities in the field of oncogenomics and to connect these investigators to our clinical partners.

Register: https://www.eventbrite.com/e/oncogenomics-tenets-of-precision-oncology-t...

11/12/2018 - 3:00pm to 5:00pm
 
Oncogenomic Tenets of Precision Oncology Symposium

Oncogenomic Tenets of Precision Oncology Symposium

Event Date/Time: 
November 13, 2018 - 8:00am to 7:30pm
Event Location: 
Speaker: 
Facility for Rare Isotope Beams, 604 South Shaw Lane, East Lansing, MI 48824
Oncogenomic Tenets of Precision Oncology Symposium

Join the Institute of Quantitative Health Science & Engineering (IQ) for the Oncogenomic Tenets of Precision Oncology Symposium, to be held Monday and Tuesday, November 12 and 13 at the FRIB Auditorium at Michigan State University.


This symposium is aimed at an audience from undergraduate students to professionals in the fields of genomics and cancer. It will be an excellent opportunity for academics and potential industrial partners to have open discussions about opportunities in the field of oncogenomics and to connect these investigators to our clinical partners.

 

Register: https://www.eventbrite.com/e/oncogenomics-tenets-of-precision-oncology-t...

11/13/2018 - 8:00am to 7:30pm
 
BME/IQ Speaker: Marios Giannakis, MD, PhD

BME/IQ Speaker: Marios Giannakis, MD, PhD

Event Date/Time: 
November 14, 2018 - 11:00am to 12:00pm
Event Location: 
IQ Atrium (775 Woodlot Dr)
Speaker: 
Marios Giannakis
Novel Targeted and Immune-based Therapies in Colorectal Cancer: from Discovery to Clinical Practice

Dr. Giannakis is a physician-scientist and faculty at the Dana-Farber Cancer Institute and Harvard Medical School. He completed his undergraduate education at the University of Toronto and pursued M.D./Ph.D degrees at Washington University in Saint Louis. His graduate work under the mentorship of Dr. Jeffrey Gordon investigated the role of Helicobacter pylori in gastric carcinogenesis. Dr. Giannakis subsequently did his Internal Medicine Residency at Brigham and Women’s Hospital in Boston and completed his Hematology/Oncology Fellowship at the Dana-Farber Cancer Institute. He was a postdoctoral fellow in the laboratory of Dr. Levi Garraway at the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard prior to becoming an independent translational and clinical investigator at the Dana-Farber and Harvard Medical School. Dr. Giannakis has numerous publications on the genomics, immunogenomics and integrative molecular epidemiology studies of colorectal cancer and is a young investigator on the Stand-Up to Cancer Colorectal Cancer Dream Team.


Research Interests:  Dr. Giannakis is interested in the development of novel therapies for patients with colorectal cancer. His group works on the genomics of colorectal cancer and performs functional studies in pre-clinical models with a focus on understanding novel mutations in Wnt-signaling genes and translating these findings into targeted therapies for molecularly defined subsets of colorectal tumors. He is also interested in developing novel immunotherapeutic approaches in this disease and study the interactions between cancer cells and the colorectal cancer microenvironment. Towards this end, we integrate the immunogenomics of colorectal cancer with pathologic and transcriptional measurements of immunity, both in large epidemiologic cohorts and in individual colorectal cancer patients undergoing therapy, in order to understand mechanisms of immune evasion and resistance. We recently have expanded our efforts to study the role of metabolism and the microbiome in colorectal cancer pathogenesis and response to therapies.

 

Join from PC, Mac, iOS or Android: https://msu.zoom.us/j/740946330
Or join by phone: +1 646 876 9923   /   Meeting ID: 740 946 330

11/14/2018 - 11:00am to 12:00pm
 
 
 
 
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Holiday - University Closed (2 days)

Holiday - University Closed (2 days)

Event Date/Time: 
November 22, 2018 - 8:00am to November 23, 2018 - 10:00pm
Thanksgiving Holiday - University closed for two full days
 
 
 
 
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BME/IQ Speaker: Margaret Petroff, PhD

BME/IQ Speaker: Margaret Petroff, PhD

Event Date/Time: 
November 28, 2018 - 11:00am to 12:00pm
Event Location: 
IQ Atrium (775 Woodlot Dr)
Speaker: 
Margaret Petroff
Novel Interactions between the Reproductive and Immune Systems: Implications for Fertility and Beyond

Dr. Margaret Petroff’s laboratory addresses two main, interrelated questions in the areas of reproductive immunology.  The first relates to the immunological paradox of pregnancy: the survival of the semiallogeneic fetus in an immunologically foreign environment – the mother.  Specific attention is paid to immunomodulatory proteins that are highly expressed in the placenta.  Ongoing studies are designed to determine local and systemic influences of placental immunomodulators on maternal immune cells, facilitated by recent findings that the placenta releases large quantities of exosomes carrying these proteins into the maternal circulation. Related efforts in the lab have expanded on the observations that in both mice and women, maternal T cells respond to specific fetal antigens that are expressed in the placenta.  Indeed, the placenta is a rich source of fetal antigens, including paternally inherited minor histocompatibility antigens and tumor antigens. The Petroff lab is performing studies to determine the short and long-term functional consequences of maternal reactivity of these antigens, with particular attention to effects of antigenic load and the surrounding endocrine, oxygen and inflammatory environments. The second major project in the Petroff lab is based on the recently identified transcriptional regulator AIRE (AutoImmune Regulator), mutations of which, in humans, cause a monogenetic autoimmune disease, Autoimmune Polyglandular Syndrome type 1. In both humans and mice, the absence of functional AIRE results in organ-specific autoimmune disease due to the emigration of autoreactive T cells from the thymus. Dr. Petroff is using Aire knockout mice to identify the immunological basis of infertility in females and males lacking this protein. Collectively these projects, all of which both use mouse and human models, have direct relevance to human conditions of infertility, pregnancy failure, autoimmune disease, transplantation, and cancer immunology.

 

Join from PC, Mac, iOS or Android: https://msu.zoom.us/j/740946330
Or join by phone: +1 646 876 9923   /   Meeting ID: 740 946 330

11/28/2018 - 11:00am to 12:00pm
 
 
 
 
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