3) Simulation of Image-Based Abdominal Aortic
Aneurysm (AAA)
Simulation
of AAA growth and remodeling (G&R) provides an
opportunity to study changes in biomechanical parameters and the
evolution of wall mechanical properties (and shear stress if coupled
with hemodynamic simulation) during growth. As a step towards
patient-specific modeling of AAA, we have extended models of
stress-mediated vascular G&R to include image-based FE models
and simulated AAAs by inducing damage to elastin.
Variety
of damage shapes for elastin (left column) and consequent forms of
growth
and stress distibutions after
G&R (right
column). The arrows indicate the regions of elevated stress
during AAA expansion.
Selected publications:
-Zeinali-Davarani
S., Baek S., 2012, Medical image-based simulation of abdominal aortic
aneurysm growth. Mechanics Research Communications, in press
-Zeinali-Davarani S., Raguin L.G., Baek, S., 2011, An inverse
optimization approach toward testing different hypotheses of vascular
homeostasis using image-based models, International Journal of
Structural Changes in Solids, 3, 33-45
-Zeinali-Davarani
S., Raguin L. G., Vorp D.A. Baek S. 2011.
Identification of in vivo material and geometric parameters of a human
aorta: toward patient-specific modeling of abdominal aortic aneurysm.
Biomech Model Mechanobiol, 10, 689-699
- Zeinali-Davarani S., Sheidaei A., Baek S. 2011. A finite element
model of stress-mediated vascular adaptation: application to abdominal
aortic aneurysms. Comput Methods Biomech Biomed Eng, 9, 803-817
- Zeinali-Davarani S., Choi J., Baek S. 2009. On parameter estimation
for
biaxial mechanical behavior of arteries. J Biomech, 42,
524-530.
Last update: Feb, 2012