Research Topics
Abdominal aortic aneurysms (AAAs) - An
AAA refers to a focal dilatation of the abdominal aorta affecting
about 5% of elderly men in the US. Even with vast increase in
understanding of AAA pathology and advances in biomedical imaging and
biomechanical analysis, rupture of AAAs continues to cause a high rate
of mortality. Although it has been shown by multiple studies that wall
stress estimated by using patient-specific geometries predicts rupture
better than the maximum diameter does, the conventional finite element
analysis still could not provide a satisfactory tool to account for the
complex structure of the diseased tissue and bio-chemo-mechanical
process during the disease development and treatment. During the past
years, we have been developing a novel computational model of AAAs that
accounts for vascular G&R during the AAA progression using
medical-image based geometries. This research is supported by NIH and
specific research topics are:
Bayesian statistics coupled with computational modeling of vascular growth and remodeling - this NSF CAREER project will illustrate that a Bayesian statistical approach can provide a break-through to overcome the difficulty in bridging the gap between biomedical modeling and clinical application.
Mechanobiology of adult stem cells - Stem cells are the most versatile and promising cell source for the regeneration of aged, injured and disease tissues. However, before stem cells can be extensively used clinically several challenges must be overcome. A major hurdle lies in designing environments that trigger the desired results. Specifically, to better control the differentiation of stem cells one must understand the intertwined roles of internal and external cues in modulating their fait. To this end, we collaborate with Dr. Chan's group to particularly study roles of coupled biomechanical and chemical stimuli on neuronal differentiation of adult stem cells. This research is supported by NSF.
Other research topics:
Research Groups
Opening
A PhD student position in theoretical/computational biomechanics is available. Send your CV to sbaekATegr.msu.edu to apply.
Abdominal aortic aneurysms (AAAs) - An
AAA refers to a focal dilatation of the abdominal aorta affecting
about 5% of elderly men in the US. Even with vast increase in
understanding of AAA pathology and advances in biomedical imaging and
biomechanical analysis, rupture of AAAs continues to cause a high rate
of mortality. Although it has been shown by multiple studies that wall
stress estimated by using patient-specific geometries predicts rupture
better than the maximum diameter does, the conventional finite element
analysis still could not provide a satisfactory tool to account for the
complex structure of the diseased tissue and bio-chemo-mechanical
process during the disease development and treatment. During the past
years, we have been developing a novel computational model of AAAs that
accounts for vascular G&R during the AAA progression using
medical-image based geometries. This research is supported by NIH and
specific research topics are: - Medical image-based simulation of abdominal aortic aneurysm growth
- Influence of hemodynamics and perivascular tissues during the progression of aortic aneurysms
- Biomechanics and vascular adaptation after endovascular aneurysm repair (EVAR)
- Fluid-Solid-Growth (FSG) interaction simulation
Bayesian statistics coupled with computational modeling of vascular growth and remodeling - this NSF CAREER project will illustrate that a Bayesian statistical approach can provide a break-through to overcome the difficulty in bridging the gap between biomedical modeling and clinical application.
Mechanobiology of adult stem cells - Stem cells are the most versatile and promising cell source for the regeneration of aged, injured and disease tissues. However, before stem cells can be extensively used clinically several challenges must be overcome. A major hurdle lies in designing environments that trigger the desired results. Specifically, to better control the differentiation of stem cells one must understand the intertwined roles of internal and external cues in modulating their fait. To this end, we collaborate with Dr. Chan's group to particularly study roles of coupled biomechanical and chemical stimuli on neuronal differentiation of adult stem cells. This research is supported by NSF.
Other research topics:
- Mechanics of soft materials (biodegradable polymer, hydrogel, controlled drug release)
- Biomaterials-hard tissue interactions (implants and prostheses)
Research Groups
- Hydrogel Engineering and Imaging Group (HEIG)
- Body Adaptation and Musculoskeletal Functions (BAMF) research
- Fluid-Solid Growth at SimTK.org
Opening
A PhD student position in theoretical/computational biomechanics is available. Send your CV to sbaekATegr.msu.edu to apply.
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