Cardiovascular
and Tissue Mechanics Research Laboratory
RESEARCH INTERESTS
The research in our group
focuses on
(1) development of
experimental and theoretical tools to characterize material behavior of
biological
soft tissues and synthetic biomaterials, and (2) development
of computational
methods for biological soft tissues to guide clinical interventions as
well as
to aid in the design of bio-instruments. Of particular interest is the
growth
and remodeling of soft tissues in response to altered
physiological and
pathological conditions, including mechanical loads, biochemical
signals,
injury, and diseases. Our group utilizes a finite element method
based on
multi-constituent continuum mechanics as a computational tool that can
account
interactions between structural components, interstitial fluid, and
cells and
production and removal of each constituent due to mechanosensitive
cellular
behaviors during the growth and remodeling. Current
research activities include development of computational
simulations of enlarging abdominal aortic aneurysms and experimental
studies of characterizing mechanical properties of large arteries.
Research topics
Biomechanics of aorta
Computational simulation of abdominal aortic aneurysm growth
Fluid-Solid-Growth (FSG) modeling in the cardiovascular system
Abinand successfully finished his thesis defense on alteration of microcirculation to changes in external loading.
Shahrokh's paper on parameter estimation for arterial mechanics is accepted for publication in Journal of Biomechanics.
RECENT PUBLICATIONS
S.
Zeinali-Davarani, J.
Choi, S. Baek, On
parameter
estimation for biaxial mechanical behavior of arteries,
Journal of Biomechanics, Vol 42, pp. 524-530, 2009
A.
Valentin, L. Cardamone, S. Baek, and J.D.
Humphrey, Complementary vasoactivity and
matrix remodeling in arterial adaptations to altered flow and pressure,
Journal
of the Royal Society Interface, Vol 6, pp. 293-306,
2009
C.A. Figueroa, S.
Baek, C.A. Taylor, J.D. Humphrey, A
computational framework for coupled fluid-solid growth model in
cardiovascular simulations, Computer Methods in Applied
Mechanics and Engineering, Vol 198, pp.3583-3602, 2009
S.
Baek and T.J. Pence, On swelling induced
degradation of fiber
reinforced polymers, to appear in International Journal of Engineering
Science (DOI 10.1016/j.ijengsci.2008.09.002)
S. Baek and J.D. Humphrey, Computational modeling of growth and
remodeling in biological soft tissues: application to arterial
mechanics, to appear in Computational Methods in Biomechanics, Springer Verlag S. Baek and T. J. Pence, Emergence and
disappearance of load induced fiber kinking surfaces in transversely isotropic
hyperelastic materials, to appear in ZAMP (doi:10.1007/s00033-009-0029-8)
A. Manorama, S. Baek, J. Vorro, T.R. Bush, Blood perfusion and transcutaneous oxygen level characterizations in human skin with changes in normal and shear loads, Clinical Biomechanics, in review
A.
Sheidaei, S.C. Hunley, L.G. Raguin, and S. Baek, Simulation of abdominal
aortic aneurysm growth with updating hemodynamic loads using a realistic
geometry, ASME Journal of Biomechanical Engineering, in review
S. Zeinali-Davarani, A. Sheidaei and S. Baek, A finite element model of stress-mediated vascular adaptation: application to abdominal aortic aneurysms, Computer Methods in Biomechanics and Biomedical Engineering, in review
