A N N O U N C E M E N T

• I currently work full-time as a Patent Examiner at the European Patent Office (EPO) in Munich, Germany. As such, I do not offer any research positions.


• Feel free to contact me for collaborations or consulting.

R E S E A R C H     I N T E R E S T S

• Biomedical Imaging using Magnetic Resonance Imaging (MRI)
  • Magnetic Resonance Microscopy
  • Diffusion-Weighted Imaging
  • Velocimetry Protocols
  • Perfusion Protocols
• Biomedical Modeling to Develop Quantitative Imaging Diagnostics and Optimize Imaging Protocols
• Bioreactors, Microfluidic Systems and Process Engineering
• Fluid Mechanics and Dynamics
• Transport Phenomena, Heat/Mass Transfer
• Chaotic Segregation

R E S E A R C H     T H R U S T S

• Thrust 1: Noninvasive and nondestructive Magnetic Resonance diagnostics for biological or bioengineered soft tissues integrated with biomechanical models


• Thrust 2: Integration of fluid mechanics and Magnetic Resonance protocols for biophysical flows and biochemical reactors


• Thrust 3: Micro-MRI and molecular MRI to investigate and treat muscle atrophy due to musculoskeletal diseases and injury

      >> View my COMMUNITY OF SCIENCE PROFILE

      >> Visit the BioFluids Magnetic Resonance Diagnostics Laboratory

High-resolution axial spin echo image of a rat brain (voxel size =
100 x 100 x 100 cubic microns)

P U B L I C A T I O N S     &     P R E S E N T A T I O N S     ( M O S T     R E C E N T )

• S. Majumdar, S.S. Udpa, L.G. Raguin,  "A Diffusion Gradient Optimization Framework for Spinal Cord Diffusion Tensor Imaging",  Magnetic Resonance Imaging  accepted for publication,  2011.

• S. Zeinali-Davarani, L.G. Raguin, S. Baek,   "An Inverse Optimization Approach toward Testing Different Hypotheses of Vascular Homeostasis using Image-based Models",   International Journal of Structural Changes in Solids,   accepted for publication,  2011.

• A. Sheidaei, S.C. Hunley, S. Zeinali-Davarani, L.G. Raguin, S. Baek,   "Simulation of Abdominal Aortic Aneurysm Growth with Updating Hemodynamic Loads using a Realistic Geometry",   Medical Engineering & Physics,   33, 80–88,  2011.

• S. Zeinali-Davarani, L.G. Raguin, D.A. Vorp, S. Baek,   "Identification of in vivo Material and Geometric Parameters of a Human Aorta: Towards Patient-specific Modeling of Abdominal Aortic Aneurysm",   Biomechanics and Modeling in Mechanobiology,   DOI 10.1007/s10237-010-0266-y,  2010.

• J. Choi, L.G. Raguin,   "Robust optimal design of diffusion-weighted magnetic resonance experiments for Skin Microcirculation",   Journal of Magnetic Resonance,   206, 246–254,  2010.

• L.G. Raguin, L. Ciobanu,  "Localized NMR velocity measurements in small channels" (book chapter),  Magnetic Resonance Microscopy: Spatially Resolved NMR Techniques and Applications,  S. Codd and J. Seymour (editors), Wiley-VCH, Weinheim, Germany,  Part Three: Transport Phenomena, Chapter 12,  2008.

C U R R E N T     R E S E A R C H     P R O J E C T S

• Development and Optimization of Quantitative Biomedical Imaging Diagnostics Tools (2006–now):   Implementation and validation of novel reconstruction methods based on functional and molecular MRI (e.g. diffusion-weighted and X-nuclei imaging) for biomedical studies (neurodegenerative and developmental diseases, ...).




Reconstruction of neuronal fibers in rat brain using diffusion-weighted MRI and a quantitative analysis of q-space MRI data (QUAQ) (from left to right): high-resolution spin echo image (100-micron in-plane resolution) used for reference, low-resolution T2-weighted spin echo image (600-micron in-plane resolution) showing the typical resolution used for diffusion-weighted MRI, fiber reconstruction assuming one neuron bundle per voxel and fiber reconstruction assuming up to two fibers per voxel using 120 diffusion-weighted images.

• Mr. Shantanu Majumdar (PhD candidate, Electrical & Computer Engineering, research assistant, Spring 2007 - now)

• Mr. Christopher D. Bolin (MS candidate, Mechanical Engineering, research assistant, Fall 2006 - Fall 2008)


• Mr. Andrew P. White (MS candidate, Mechanical Engineering, research assistant, Fall 2007 - Fall 2008)


• Mr. Daryoosh Derakhshan (BS candidate, Physiology, research aid, Summer 2007 - Fall 2007)


• Mr. Atha Khan (MS candidate, Mechanical Engineering, research assistant, Summer 2007 - Fall 2007)


• Ms. Xuhui Zhao (PhD candidate, Mechanical Engineering, research aid - Fall 2006)

• Mr. Gaël Cordier (Engineering Diploma candidate, Ecole Catholique d'Arts et Métiers, Lyon, France, research aid, August 2007 - now)

S O M E     P A S T     R E S E A R C H     P R O J E C T S

• Quantitative diffusion-weighted MRI (2004–2006):   Development of a reconstruction method for quantitative diffusion-weighted MRI tractography: QUAQ.


• Micro-MRI velocimetry for microfluidic systems (2004–2006):   Development and comparison of micro-MRI velocimetry protocols for microfluidic systems.


• Characterization of physical and transport properties in hydrogels via NMR/MRI (2005–2006):   Extraction of physical and transport properties of various hydrogels (Agar, PEG, HEMA) using Nuclear Magnetic Resonance (NMR) to help design, fabricate and characterize novel hydrogel-bridged nanofluidic polycarbonate membranes.


• Theoretical, numerical and experimental study of a novel separation system (2000 - 2004):   Investigated kinematics, separation and chaotic advection in complex 3-D swirling flows via MRI techniques (spin-tagging and phase-contrast velocimetry, pulsed-field gradient dispersion measurements) and numerical analysis of the dynamic motion equations.

T E A C H I N G

• Fall 2008: ME 812 "Conductive Heat Transfer" - Graduate course. Topics include: one-, two-, three-dimensional heat conduction problems, solutions with separation of variables, integral transform technique, Laplace transforms, numerical analysis, and Duhamel's method.
  
  

  Guest lecture: "Diffusion of thermal disturbances in multi-dimensional transient heat conduction" by Prof. Filippo de Monte, Associate Professor in Mechanical Engineering, Division of Heat Transfer and Applied Thermodynamics, University of L'Aquila, Italy on Wednesday, November 28, 2007, at 8:00 am. Abstract: The lecture analyzes the diffusion of thermal disturbances in heat-conducting multi-dimensional bodies through characteristic times, such as penetration and deviation times, denoting their negligible effects. A single basic criterion governing the above diffusion is derived thanks to the similarity of the findings. It allows very accurate solutions to be obtained considering only the physical region of interest in place of considering the complete body. Therefore, it is efficient in terms of computational savings in numerically based methods as well as analytical techniques. In the former case, the grid domain can considerably be reduced. In the latter case, the number of terms needed to obtain long-time solutions when time-partitioning is applied can significantly be limited. Also, complex 1D and 2D semi-infinite problems are solved explicitly and evaluated numerically as part of the analysis.

  Prof. Filippo de Monte Division of Heat Transfer and Applied Thermodynamics University of L'Aquila, Italy

• Spring 2007: ME 332 "Fluid Mechanics" - Lecture for two sections of junior undergraduate students.
  Topics include: fluid statics, fluid kinematics, Bernoulli's equations, system and control volume (conservation of mass, Newton's second law, conservation of energy), differential analysis of fluid flow (continuity, Euler, Navier-Stokes equations), dimensional analysis and similitude, laminar flow and turbulent flow in a pipe, laminar boundary layers and turbulent boundary layers, drag and lift


• Fall 2006: ME 481 "Capstone Design Project" - Academic Advising of a group of 4 senior undergraduate students.

S E R V I C E

• 2007 to 2008: Serves on the organizing committee for the Department of Mechanical Engineering Seminar Series with Profs. P. Kwon, S. Baek, and J. Choi.

Organized seminars:


• 2007, October 23: "3D Magnetic Resonance Carotid Plaque Imaging" by David C. Zhu, Ph.D., Cognitive Imaging Research Center, Biomedical Imaging Research Center, Departments of Psychology and Radiology, Michigan State University.

• 2008, January 29: "MRI and biomechanical modeling of the ACL injured knee" by Thomas Buchanan, Ph.D., Department of Mechanical Engineering, University of Delaware.

• 2008, April 8: "Computational Investigations of Gravity and Turbidity Currents" by Eckart Meiburg, Ph.D., Department of Mechanical Engineering, University of California at Santa-Barbara.

• 2007, November 10: Served as a presentation judge at the Spartan FIRST LEGO League Challenge - East Lansing Regional Tournament held at Michigan State University, East Lansing, MI.

• 2007: Co-chaired the "Biomedical Engineering I" session at the 13th International Symposium on Applied Electromagnetics and Mechanics (ISEM 2007), September 9–12, 2007, Michigan State University, East Lansing, MI.

• 2006-2007: Served on the organizing committee and chaired four sessions of the 2007 Inverse Problem Symposium (IPS 2007), June 11 & 12, 2007, Michigan State University. This is the 20th in the series of National and International Meetings on Inverse Problems that were initiated at Michigan State University in 1988. Topics include Mathematical and Statistical Aspects of Inverse Problems, Design of Experiments, and Applications in Heat Transfer, Applied Mechanics, Biology, Biochemistry, Genetics, Medicine, Nondestructive Evaluation, Tomography, Inverse Scattering, Geology, Environmental Phenomena, Economics, and more.

• Technical reviewer for the IEEE Transaction on Medical Imaging, Biomechanics and Modeling in Mechanobiology, the 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, the 20th Inverse Problem Symposium, the International Journal of Applied Electromagnetics and Mechanics, the Journal of Heat Transfer, and the Materials Research Society.

E D U C A T I O N

• Ph. D.  Mechanical Engineering, University of Illinois at Urbana-Champaign (UIUC), Urbana, USA, 2004. Thesis: "Theoretical and Experimental Study of a Continuous Hydrodynamically-Enhanced Separation System Paradigm"


• M. S.  Mechanical Engineering, UIUC, Urbana, USA, 2000.Thesis: "Experimental Study of Mass Transport and Flow Structures in Taylor-Couette-Poiseuille Flows Using MRI".


• Engineering Diploma  Energy/Materials Science, Ecole National Supérieure des Mines de Nancy (ENSMN), Institut National Polytechnique de Lorraine (INPL), Nancy, France, 1999. Thesis: "Radial and Axial Dispersion in Taylor-Couette and Poiseuille Helical Flows"


• B. S.  Energy/Materials Science, ENSMN, INPL, Nancy, France, 1998.

      >> Download my Curriculum Vitae: PDF (4 pages).

      >> Download my 2-page Resume: PDF (2 pages) or 5-page Resume: PDF (5 pages).

C O N T A C T     I N F O R M A T I O N

L. Guy Raguin
Department of Mechanical Engineering
Michigan State University
Mail:   2555 Engineering Building
East Lansing, MI   48824-1226,   USA
Fax:   +1 517 353-1750
Web:   http://www.egr.msu.edu/~raguin