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Michigan State University

National Science Foundation

Instrument Development for Biological Research

Project Overview

Temperature Controlled Array Microsystem for Functional Proteomics

NSF Grant DBI-0649847

Principle Investigator: Andrew J. Mason (mason@mus.edu), Associate Professor, Electrical/Computer Engineering
Co-Investigators:    R. Mark Worden (worden@msu.edu ), Professor, Chemical Engineering
                                 R. Michael Garavito (garavito@msu.edu), Professor, Biochemistry
                                 Paul Sato, Adjunct Professor and VP of Research, Neogen Corp.

The goal of this project is to develop an integrated microsystem platform that can incorporate an array of bio-interfaces into a cost-effective, highly accurate, continuous-use, electrochemical characterization system suitable for a wide range of proteins. This device would provide revolutionary capabilities for protein characterization, including (1) simultaneous activity measurement for many soluble and membrane proteins, (2) rapid, automated interrogation using multiple electrochemical techniques, (3) microthermoregulation of individual protein sites, and (4) reduced costs per assay.

Novel bio-interfaces would provide new methods to measure activities of thermophilic proteins and develop protein-based technologies (e.g., biosensors). Molecular self-assembly of bio-interfaces would facilitate automated functionalization of the array. Embedded temperature control would allow a novel “cold sensing” technique that would prolong the lifetime of expensive proteins and reagents. A new, adaptive circuit topology would enable multiple electrochemical interrogation methods on a single chip, including an innovative method for rapid, low-frequency impedance spectroscopy.

Project Focus Areas

• Biomimetic Interfaces
• Array Fabrication
• Thermal Control
• Electrochemical Readout
• Microsystem Integration

Resources

• Center for Biomimetic Interfaces
• NSF Center for Wireless Integrated Microsystems

Project Objectives

Biomimetic Interfaces

Lead researcher:

Project overview:

Publications:

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