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Microfluidic Bioprocessing

microfluidic sorting
Microfluidics offers several advantages over conventional benchtop techniques including minimal reagent consumption, faster processing times, improved precision and reduced overall device size. Based on this technology, we are developing portable platforms to improve the performance of current bioprocessing techniques including cell separation/sorting, particle manipulation,cell lysis and biomolecular concentration.

Coffee Ring Biosensor

coffee ring biosensor
The coffee ring effect is a common phenomenon that occurs when a droplet of colloid solution evaporates on a solid surface, resulting in the formation of a coffee ring spot. We employ this principle for biomolecular concentration for subsequnt protein detection. Using this approach, we are able to achieve significant signal enhancement of our optical-based biosensor without the use of additional equipment or labor-intensive sample amplification, thus offering a simple and inexpensive diagnostic platform.

Point-of-care Diagnostics

BoNT lab on a chip
Through the integreation of multiple technologies, we are creating point-of-care platforms for the detection of various analytes, toxins and biomolecules. Rapid detection is achieved by implementing electrical biosensors, which offer high sensitivity, multiplexing and quantitative measurments. Additionally, we are designing these systems with autonomous capabilities for enhanced portability and ease of use.

Surface Modification

surface modification
We are investigating various techniques to modify the physical, electrical and chemical properites of surfaces for enhanced functionality. Specifically, we are developing robust surface treatments for various applications including capillary flow, biomolecular patterning and biosensing.

We gratefully thank our sponsors:

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