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Animal testing is sometimes necessary to find out how toxic substances might harm people or to treat those who have been exposed. Laws today protect the welfare of research animals and scientists must follow strict guidelines. People exposed to PCBs in the air for a long time have experienced irritation of the nose and lungs, and skin irritations, such as acne and rashes.
It is not known whether PCBs may cause birth defects or reproductive problems in people. Some studies have shown that babies born to women who consumed PCB-contaminated fish had problems with their nervous systems at birth. However, it is not known whether these problems were definitely due to PCBs or other chemicals.
Animals that breathed very high levels of PCBs had liver and kidney damage, while animals that ate food with large amounts of PCBs had mild liver damage. Animals that ate food with smaller amounts of PCBs had liver, stomach, and thyroid gland injuries, and anemia, acne, and problems with their reproductive systems. Skin exposure to PCBs in animals resulted in liver, kidney, and skin damage.
It is not known whether PCBs causes cancer in people. In a long-term (365 days or longer) study, PCBs caused cancer of the liver in rats that ate certain PCB mixtures. The Department of Health and Human Services (DHHS) has determined that PCBs may reasonably be anticipated to be carcinogens.
There are tests to find out if PCBs are in your blood, body fat, and breast milk. Blood tests are probably the easiest, safest, and best method for detecting recent exposures to large amounts of PCBs.
However, since all people in the industrial countries have some PCBs in their bodies, these tests can only show if you have been exposed to higher-than-normal levels of PCBs. However, these measurements cannot determine the exact amount or type of PCBs you have been exposed to or how long you have been exposed. In addition, they cannot predict whether you will experience any harmful health effects.
The EPA has set a maximum contaminant level of 0.0005 milligrams PCBs per liter of drinking water (0.0005 mg/L). The EPA requires that spills or accidental releases into the environment of 1 pound or more of PCBs be reported to the EPA.
The Food and Drug Administration (FDA) requires that milk, eggs, other dairy products, poultry fat, fish, shellfish, and infant foods contain not more that 0.2–3 parts of PCBs per million parts (0.2–3 ppm) of food.
ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.
Agency for Toxic Substances and Disease Registry
Division of Toxicology
1600 Clifton Road NE,
Mailstop E-29 Atlanta, GA 30333
Phone: 1-800-447-1544
FAX: 404-639-6315
U.S. Department of Health and Human Services
Public Health Service
Agency for Toxic Substances and Disease Registry
The Midwest Hazardous Substance Research Center, Michigan
State University.
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