Health

Photo for Health Research of Tim Whitehead and a student in the lab.

Expanded research in this area is a top priority of the college. There are several groups on which we will base our growth: nanomedicine for diagnosis and treatment, as well as for drug development; identification of critical paths in selected proteomic processes (e.g., renal, cardiovascular), using a system biology approach; and device development (e.g., telemedicine for breast examinations, non-invasive diagnosis of cardio- and other critical functions, ultrasound and microwave imaging and therapy, tissue engineering, neuroprosthetics, and new sensor development).

Strength Areas

  1. Bioinformatics, Systems and Computational Biology:  Post Genome Era: Reverse Engineering Living Systems
    Titus Brown, Seungik Baek, Christina Chan, Erik Goodman, Yanni Sun
  2. Drug Delivery, Protein and Thermal Therapeutics, and Tissue Engineering and Mechanics:
    Seungik Baek, Melissa Baumann, Tamara Reid Bush, Christina Chan, Roger Haut, Robert Mcgough, Jeff Sakamoto, Pat Walton, Tim Whitehead, Neil Wright
  3. Biosensors, Biomimetic Surfaces, and Monitoring and Detection Devices:
    Evangelyn Alocilja, Shantanu Chakrabartty, Lixin Dong, Syed A. Hashsham, Peter Lillehoj, Andrew Mason, Arjun Tekalur, Mark Worden, Irene Xagoraraki
  4. Signal and Image Processing:
    Sara Aviyente, John Deller, Ramakrishna Mukkamala, Karim Oweiss, Yiying Tong, Lalita Udpa, Satish Udpa

Strength Areas by Faculty

  • Evangelyn C. Alocilja: development of nanoparticle-based biosensors for rapid, point-of-care/on-site detection and diagnosis of disease-causing agents and adulterants of concern to global health, homeland security, food/water safety, and product integrity.
  • Sara Aviyente: theory and applications of statistical signal processing, in particular non-stationary signal analysis; developing methods for efficient signal representation, detection and classification; applications of signal processing to biological signals such as the analysis of event related brain potentials; study of the functional networks in the brain
  • Seungik Baek's group is working on cardiovascular and tissue mechanics and a particular focus is on developing a biomechanical, statistical method to predict progression and risk of aortic aneurysms.
  • Melissa Baumann: processing/characterization of biomaterials for tissue engineering (bone, cartilage). Optimizing cell biomaterial interactions. Materials science: processing behavior of ceramics and ceramic composites, surface chemistry and colloidal chemistry
  • C. Titus Brown: computational biology, bioinformatics, open source software development, and software engineering
  • Tamara Reid Bush conducts in vivo experimentation, methods development, and modeling to better understand clinically motivated problems connected with human movement and force generation. Click here to read more about this research.
  • Shantanu Chakrabartty: three aspects of hybrid circuits and systems: MORPHING - Investigating neural inspired circuits; SYNTHESIS - Using hybrid computational elements (biological and silicon) to design biomolecular circuits and systems; MONITORING - Embedded and implantable monitoring of natural and engineered systems
  • Christina Chan's research is focused on understanding the signaling and regulatory mechanisms that are altered in diseases, such as obesity, Alzheimer’s disease and cancer. Her group develops and applies metabolic engineering, bioinformatics, and systems biology approaches in combination with biochemical, biophysical, and molecular biology measurements and animal studies to identify targets and disease biomarkers. Her group also is developing polymeric-based drug delivery and tissue engineering platforms to modulate these pathways for treating these diseases. Click here to read more about this research.
  • John Deller: statistical signal processing with applications to speech and hearing, genomics, and other aspects of biomedicine
  • Lixin Dong: anorobotics, nanoelectromechanical systems (NEMS), mechatronics, mechanochemistry, and nanobiomedical devices
  • Erik Goodman: evolutionary computation, particularly heterogeneous and parallel genetic algorithms and genetic programming
  • Syed A. Hashsham: environmental and molecular microbiology, bioremediation, environmental genomics using microarrays,  modeling microbial ecosystems
  • Roger Haut: impact-trauma biomechanics, orthopaedic biomechanics, experimental mechanics
  • Andrew Mason: mixed-signal integrated circuits and microfabrication to addresses challenges in microsystem development for biochemical, neural, and environmental sensing applications
  • Robert McGough: biomedical ultrasonics and electromagnetics, thermal therapy, targeted drug delivery, and medical imaging
  • Ramakrishna Mukkamala: biomedical signal processing and identification, modeling of physiologic systems, and cardiovascular physiology
  • Karim Oweiss: statistical signal processing, neural integration and coordination in sensorimotor systems, neural mechanisms of plasticity and learning, computational neuroscience. Applications in neuroinformatics, neuroprosthetics and brain-machine interfaces
  • Jeff Sakamoto: ultraporous inorganic and organic gels for energy and biomedicine
  • Yanni Sun's research interests are bioinformatics, computational biology, and developing algorithms and software to solve problems motivated by molecular biology. Her recent focus is efficient algorithms for discovering protein and noncoding RNA signals hidden in large-scale databases
  • Arjun Tekalur: dynamic behavior of biomimetic materials, dynamic failure of biological materials (special attention to bone)
  • Yiying Tong: discrete geometric modeling, physically-based simulation/animation, and discrete differential geometry. His research interests also include the applications of differential geometry in face recognition, molecular surface computation, medical imaging
  • Lalita Udpa: development of image processing techniques for automated analysis of NDE and biomedical images
  • Satish Udpa's research interests span the broad area of materials characterization and nondestructive evaluation (NDE). Work done by him to date in the area includes an extensive repertoire of forward models for simulating physical processes underlying several inspection techniques. Coupled with careful experimental work, such forward models can be used for designing new sensors, optimizing test conditions, estimating the probability of detection, assessing designs for inspectability and training inverse models for characterizing defects.
  • S. Patrick Walton: biomolecular engineering, thermodynamic and kinetic design of biomolecules, nucleic acid biotechnology, genomics and proteomics, RNA interference, nanobiotechnology, polymeric nanoparticles. Click here to see a video about Patrick Walton's research.
  • Tim Whitehead: development of antibody and antibody-like molecules for use as protein therapeutics against viral pathogens. Click here to see a video and read more about Tim Whitehead's research.
  • Mark Worden: nanotechnology, nanostructured biomimetic interfaces; biochemical engineering; protein expression; fermentation engineering; multiphase biocatalysis; biobased products
  • Neil Wright: measuring multi-axial thermophysical properties of elastomers and biological soft tissues that are subjected to finite multi-axial deformation; thermomechanically-induced damage to proteins, cells, and tissues. biomedical; polymer; nonlinear mechanics
  • Irene Xagoraraki: water quality engineering, drinking water safety and public health; detection, removal and inactivation of emerging biological and chemical contaminants in water systems

Evangelyn C. Alocilja's research, extracting DNA in PCR station

Blood flow behavior inside three different Abdominal Aortic Aneurysms

Tamara Reid Bush's research in human body mechanics: hand functionSyed Hashsham developed a mobile diagnostic device capable of detecting some of the world's most deadly diseases.

Roger Haut in the research lab.Karim Oweiss (1st left) in the lab with his students.Arjun TekalurPhoto of Irene Xagoraraki with students in lab

Click here to read more about our faculty in Health Research. Or click on the Research-Related Faculty block in the upper right corner.