The Protein Expression Laboratory (PEL) at Michigan State University was established with funding by the Michigan Life Sciences Corridor to assist scientists with non-GMP production of recombinant proteins using microbial expression systems. The PEL provides a set of services including gene cloning, computer-controlled fermentations, fermentation optimization and scale-up, cell lysis, protein assay, protein purification and final product freeze drying. The PEL has successfully produced a variety of proteins for functional and structural studies, bioconversion, pre-clinical trial, biosensors, antibody development, etc.