In this NSF CAREER Award, Dr. Dong plans to integrate research and educational activities to contribute to the development of both technologies and human resources in the field of nanorobotics and nanosystems focusing on building functionalized end-effectors from nanosystems for intelligent nanorobotic manipulation. This is achieved using segment-nanostructure-based nanoelectromechanical systems (NEMS) and nanophotonic systems. Internal electron tunneling and optical coupling are used as the common base of these end effectors for achieving high resolution while keeping to nano scale. The advancement in this field will broaden both the scopes of robotics and nanotechnology, lead to new tools for nanomanufacturing and other engineering fields including the electronics and microscopy industry, enable novel devices with the potential to remarkably enhance the energy adsorption for solar cells, and offer deep insights for nanoelectronics and nanophotonics. Applications are found in single molecule manipulation in biology, material characterization, inter-molecule interactions in supramolecular chemistry, and intelligent tools for future nanorobotic medicine. By integrating with the research efforts, broad outreach is achieved through lectures, workshops, courses and websites for K-12 students and teachers, as well as for the public who have an interest in this emerging field.