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Syed A. Hashsham, Ph.D.

Civil and Environmental Engineering
A126 Engineering Research Complex
East Lansing, MI 48824

Phone: (517) 355-8241
Fax: (517) 355-0250
E-Mail: hashsham@egr.msu.edu
Web (Lab): http://www.egr.msu.edu/~hashsham/

Courses Taught:

  • Biological Principles of Environmental Engineering
  • Microbiology for Environmental Health Engineering
  • Feasibility Studies in Environmental Engineering
  • Introduction to Environmental Engineering

Recent Research:

  • On-chip PCR
  • Flexible Biochip for Highly Parallel Microbial Detection
  • GeneScreen: A low-cost and high-density DNA biochip for detecting up to 30,000 microorganisms
  • Development of microarrays for evaluating phylogenetic and functional diversity of the microbial world
  • Bioinformatics Pilot Program for the Assessment of Virulence-Factor and Activity relationships (VFARs) for Waterborne Disease Microorganisms
  • Emerging microbial indicator technologies
  • Landfill Bioreactors: Field Scale Evaluation
  • Sustainable Manure Management in Dairy Industry by Struvite Recovery


Dr. Hashsham’s research focuses on environmental molecular biology and mathematical tools to address environmental engineering issues. Current research focuses on the development of DNA biochips for parallel detection of microorganisms important to drinking water and wastewater. Approaches for improved detection limit, sample concentration, probe design, and validation are of special interest. Dr. Hashsham is also interested in developing new tools to manage mixed microbial communities and bioreactor landfills.


University of Illinois at Urbana-Champaign: Ph.D., Environmental Engineering

Selected Publications:

  • Lukas M. Wick, Jean Marie Rouillard, Thomas S. Whittam, Erdogan Gulari, James M. Tiedge and Syed A. Hashsham, On-chip non-equilibrium dissociation curves and dissociation rate constants as methods to assess specificity of oligonucleotide probes, Nucleic Acids Research, 34(3):e26; doi: 10.1093/nar/gnj024, 2006.
  • Duran, M., Alm, E. W., Stedtfeld, R. D., Haznedaroglu, B. Z., and Hashsham, S. A., Detection and Occurrence of Indicator Organisms and Pathogens, Water Environment Research, Vol. 77, No. 6, pp. 659-717, 2005.
  • Hashsham, S.A., Wick, L.M., Rouillard, J-M., Gulari, E., and J.M. Tiedge, Potential of DNA microarrays for developing parallel detection tools (PDTs) for microorganisms relevant to biodefense and related research needs, Biosensors and Bioelectronics, Volume 20, Issue 4, Pages 668-683, 2004.
  • Denef, V.J., J. Park, J.L. Rodrigues, T.V. Tsoi, S.A. Hashsham and J.M. Tiedje, Validation of a more sensitive method for using spotted oligonucleotide DNA microarrays for functional genomics studies on bacterial communities, Environmental Microbiology, 5(10), 933-943, 2003.
  • Sun, B., B.M. Griffin, R.K. Kehrer, S.A. Hashsham, and J.M. Tiedge, Microbial reductive dechlorination of 1.1.1-trichloroethane to chloroethane, Science, 298: 1023, 2002.
  • Dollhopf, S.L., S.A. Hashsham, and J.M. Tiedge, Interpreting 16S rDNA T-RFLP Data: Application of self-organizing maps and principal component analysis to describe community dynamics and convergence, Microbial Ecology, 42 (4): 495-505, 2001.
  • Hashsham, S., A. Fernandez, S. Dollhopf, F. Dazzo, R. Hickey, J. Tiedje, and C. Criddle, Parallel processing of substrate correlates with greater functional stability in methanogenic bioreactor communities perturbed by glucose, Applied and Environmental Microbiology, 66 (9): 4050-4057, 2000.
Phone: (517) 355-5107 Fax: (517) 432-1827 E-mail: cee@egr.msu.edu
Department of Civil and Environmental Engineering
Michigan State University
Engineering Building
428 S. Shaw Lane, Room 3546
East Lansing, MI 48824