Linxia Zhang
zhanglin(at)msu.edu
PI:
Christina Chan
Lab:
517-432-1003
Michigan State University
2125 Engineering Building
East Lansing, MI 48824
Hometown:
Zhejiang, China
Undergraduate Institution:
Fudan University
Project title:
Effect of cAMP on Mesenchymal Stem Cell Fate Determination
Project Description:
can undergo both self-renewal and multi-lineage differentiation. As an important intracellular second messenger, cAMP was shown to induce the differentiation of MSCs into neural cells. Elevation of cAMP level is usually associated with the activation of the CREB (cAMP response element binding protein) family proteins. Among the CREB family protein target genes, some are cell cycle regulators such as cyclin A and cyclin D1. While activated CREB induces the transcription of these genes, another member of the CREB family protein called ICER (inducible cAMP early repressor) inhibits their transcription by competing with CREB for binding to the CRE motif. Concerted action of CREB and ICER controls the expression of cyclin A and cyclin D1 and consequently affecting proliferation and differentiation of MSCs.
Personal Interests:
movies, music, reading, some sports