Tim Whitehead
Biography:
We are a young lab that designs and engineers functional proteins. We are focused on the development of computational and experimental tools as well as two major areas for the application of these methods: (1) the microbial-mediated conversion of biomass to fuels and chemicals that more closely approximate petroleum-derived feedstocks; and (2) development of antibody and antibody-like molecules for use as protein therapeutics against viral pathogens.
Publications:
T.A. Whitehead*, A. Chevalier*, Y. Song, S.J. Fleishman, C. Dreyfus, C. de Mattos, C.A. Myers, H. Kamisetty, P. Blair, I.A. Wilson, D. Baker, "Influenza neutralization based on complete fitness landscapes of computationally designed inhibitors," submitted (2011)
Fleishman SJ, Whitehead TA, Strauch EM et al. "Community-wide assessment of protein-interface modeling suggests improvements to design methodology," J Mol Biol accepted (2011)
S.J. Fleishman*, T.A. Whitehead*, D. Ekiert*, C. Dreyfus, J.E. Corn, E.M. Strauch, I.A. Wilson, D. Baker "Computational design of proteins targeting the conserved stem region of Influenza hemagglutinin," Science 332(6031):816-21 (2011)
T.A. Whitehead, L.M. Bergeron, D.S. Clark, "Tying up the loose ends: circular permutation decreases the proteolytic susceptibility of recombinant proteins" Protein Eng Des Sel 22 (10):607-13 (2009)
Education:
Ph.D., Chemical Engineering, University of California, Berkeley, 2008
B.E., Chemical Engineering, Vanderbilt University, 2001