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Design Team (left to right): Sarvinder Sandhu,
Fawn Buckley, Kevin BelenDried Blood Storage Device: The research teams at Pfizer’s Global Research and Development in Ann Arbor, MI develop new drugs. In this process, it is necessary to take aliquots of blood samples from mice to conduct pharmacokinetic and pharmacodynamic tests to study drug affects. Minimal aliquots of blood should be taken at every collection time in order to decrease stress to the mouse. The current blood sampling and analysis procedure includes using Whatman 903® Specimen Collection Paper, which holds five dried blood samples per sheet. Aliquots of blood, up to 100μL, are dried and then prepared for analysis using mass spectrometry. Current sample preparation technology does not allow the efficient use of sampled blood.
In order to facilitate the research process, the Dried Blood Storage team designed an optimized sheet of 903 filter paper. This design fits directly on top of a 96 well plate and is capable of storing 96 aliquots of blood. Additional features of the design include a barrier system to prevent cross contamination between sample sites and a labeling system for user friendliness. The design allows for the rapid automation of the storage, reconstitution, and analysis of blood, while maximizing the use of each blood sample.
Industry Advisors: Lucinda Cohen, PhD, and
Lisa Buchholz, Pfizer Global Research and Development,
Ann Arbor, MI.This article was written for publication in the Senior Design Showcase Program, April 17, 2007. Biosystems and Agricultural Engineering Newsletter, Michigan State University, East Lansing, MI
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