The ABEL is focused on the analysis and application of nucleic acid-based technologies. Our goals are the understanding of critical biophysical and biochemical parameters involved in these processes and, in turn, the tuning of these parameters to achieve an improved technology. The current foci of the lab fall into two categories: i) mechanistic analysis of RNA interference (RNAi) and ii) parallel analytical platforms for cellular molecules. Specific ongoing projects include:

1.) in vitro interactions of RNAs with human RNAi pathway proteins

2.) Delivery of siRNAs by nanoparticles