Cardiovascular
and Tissue Mechanics Research Laboratory
RESEARCH INTERESTS
The research in our group
focuses on
(1) development of
experimental and theoretical tools to characterize material behavior of
biological
soft tissues and synthetic biomaterials, and (2) development
of computational
methods for biological soft tissues to guide clinical interventions as
well as
to aid in the design of bio-instruments. Of particular interest is the
growth
and remodeling of soft tissues in response to altered
physiological and
pathological conditions, including mechanical loads, biochemical
signals,
injury, and diseases. Our group utilizes a finite element method
based on
multi-constituent continuum mechanics as a computational tool that can
account
interactions between structural components, interstitial fluid, and
cells and
production and removal of each constituent due to mechansensitive
cellular
behaviors during the growth and remodeling. Current
research activities include development of computational
simulations of enlarging intracranial aneurysms, development of a
diagnostic
tool for cell-seeded hydrogels, and experimental studies of relation
between
microcirculation of a skin and applied forces as a precursor of
decubitus
ulcers.
Current Research Projects
Estimation of aneurysm growth rates and rupture potential based on
biomedical images
Development of a computational framework for coupled
Fluid-Solid-Growth (FSG) modeling in the cardiovascular system
Parameter estimation for
biaxial mechanical behavior of arteries
Constitutive modeling of degradable hydrogels
Body adaptation and musculoskeletal functions (BAMF)
research
Some Past
Research Projects
Study on stability of intracranial aneurysm growth
Biochemomechanical modeling of cerebral vasospasm
Modeling of pH sensitive hydrogel
Alteration of mechanical behavior of thermally damaged
tissues
Jungsil Kim (PhD candidate, research assistant &
lab manager, Spring 2007 ~ )
Shahrokh Zeinali (PhD candidate, research assistant, Fall
2007 ~ )
William Smits (MS candidate, Fall 2007 ~ , co-advising
with Prof. Choi)
Abinand Anbazhaganmanorama (MS candidate, Summer 2007~, co-advising with Prof. Bush)
Azadeh Sheidaei (MS candidate, Summer 2008, co-advising with Prof. Raguin)
Stanley Christopher Hunley (Summer intern, Summer 2008)
Past staffs
Undergraduate researchers: Nicholas
Beechnau (BS, Spring 2007 ~ Spring 2008), Megan Galdes (Fall
2006~Spring 2007), Nicole Arnold (Summer intern, 2007)
The cardiovascular and tissue mechanics research lab is
featured on ME Bulletin Spring 2008. Read more.
Spring 2008: Congratulation to Nicholas Beechnau, who
received an admission from MSU Osteopathic Medical School !
Dr. Baek received 2007 IRGP award from MSU.
RECENT PUBLICATIONS
E. Wandell, N.
Beechnau, W. Smits, S. Baek, J. Choi, M. de Zee, T.R. Bush, Computer model analysis of
cervical lateral function for symmetric and asymmetric/symptomatic
subject groups, Program Book with
Abstract, World Congress on Neck Pain, pp. 132-133, Los Angeles CA, 2008
J.D. Humphrey, P.B.
Wells, S. Baek, A. Lai, K. McLerod, A. Yeh, A theoretically-motivated
biaxial tissue culture system with intravital microscopy, Biomechanics
and Modeling in Mechanobiology, in print, 2008
A.
Valentin, L. Cardamone, S. Baek, and J.D.
Humphrey, Complementary vasoactivity and
matrix remodeling in arterial adaptations to altered flow and pressure,
Journal
of the Royal Society interface, submitted, 2008
Shahrokh
Zeinali, Jongeun Choi, Seungik Baek, Parameter
estimation of mechanical behavior
of the artery using a nonlinear least
square method with a noise model, Proceedings of the ASME
Summer
Bioengineering Conference, June 25-29, Marco Island, FL, 2008
Seungik Baek, C. Alberto Figueroa,
Charles A. Taylor,
Jay D. Humphrey, A framework for
fluid-solid-growth modeling and its application to understanding the
enlargement of a fusiform aneurysm, Proceedings of the ASME
Summer
Bioengineering Conference, June 25-29, Marco Island, FL, 2008
C.A. Figueroa, S.
Baek, C.A. Taylor, J.D. Humphrey, A
computational framework for coupled fluid-solid growth model in
cardiovascular simulations, Computer Methods in Applied
Mechanics and Engineering, submitted, 2008
S. Zeinali, J.
Choi, S. Baek, Parameter
estimation for biaxial mechanical behavior of the passive arteries,
Journal of Biomechanics, in preparation, 2008
Seungik
Baek and Thomas J. Pence, On swelling induced
degradation of fiber
reinforced polymers, International Journal of Engineering
Science, submitted, 2008
C. Alberto Figueroa, Seungik Baek, Charles A. Taylor,
Jay D. Humphrey, Multi-scale modeling of
blood vessels using a Fluid-Solid Growth framework, The 8th
World Congress on Computational Mechanics, June 30-July 5, Venice, Italy, 2008
A. A. Manorama, S. Baek, T. R. Bush, Blood flow and oxygen level characterization
of the forearm with changes in normal and shear load, North American
Congress on Biomechanics, August 5-9, Ann Arbor, Michigan, 2008
